Title of article :
Stereoselective total synthesis of pachastrissamine (jaspine B)
Author/Authors :
Passiniemi، نويسنده , , Mikko and Koskinen، نويسنده , , Ari M.P. Koskinen، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
A short total synthesis of the cytotoxic natural product pachastrissamine is described. The synthesis includes eight steps starting from Garner’s aldehyde and proceeds in 20% overall yield. Pd(0)-mediated intramolecular cyclisation and Ru-mediated cross-metathesis are the key reactions in this sequence.
Keywords :
enantioselective synthesis , natural products , Pachastrissamine , Cross metathesis , cyclization
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
