Title of article :
A facile and efficient one-pot synthesis of thiirans by the reaction of benzoxazolyl β-ketosulfides with NaBH4/NaOH
Author/Authors :
Yamada، نويسنده , , Nobuhiko and Mizuochi، نويسنده , , Masayoshi and Takeda، نويسنده , , Masahiro and Kawaguchi، نويسنده , , Hiroyuki and Morita، نويسنده , , Hiroyuki، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
Convenient and efficient procedures for thiirans have been developed via a one-pot reaction of benzoxazolyl β-ketosulfides with NaBH4 and NaOH in MeOH and THF. The reaction is considered to proceed via the spiro intermediate by the ipso-addition of β-hydroxygroup, which is formed by the NaBH4 reduction of β-keto group, to 2-position of benzoxazole group.
Keywords :
Thiirans , ?-Ketosulfides , one-pot synthesis , benzoxazole
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
