Title of article
Microwave-based synthesis of novel thienopyrimidine bioisosteres of gefitinib
Author/Authors
Manisha S. Phoujdar، نويسنده , , Manisha S. and Kathiravan، نويسنده , , Muthu K. and Bariwal، نويسنده , , Jitender B. and Shah، نويسنده , , Anamik K. and Jain، نويسنده , , Kishor S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
5
From page
1269
To page
1273
Abstract
A series of novel 2-unsubstituted 4-(substituted)anilinothieno[2,3-d]pyrimidines is synthesized through the chlorination of the corresponding 2-unsubstituted-thieno[2,3-d]-pyrimidin-4-ones, followed by the nucleophilic displacement of the 4-Cl group of 9, with a variety of anilines. All four steps of this synthesis involve microwave irradiation (MWI) and the entire synthesis requires only 2 h.
Keywords
MWI , 3-d]pyrimidines , Library synthesis
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858260
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