Title of article
A facile intramolecular azido/amido reductive cyclization approach: synthesis of pyrrolobenzodiazepines and their dimers
Author/Authors
Kamal، نويسنده , , Ahmed and Shankaraiah، نويسنده , , N. and Markandeya، نويسنده , , N. and Reddy، نويسنده , , K. Laxma and Reddy، نويسنده , , Ch. Sanjeeva، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
1465
To page
1468
Abstract
A new synthetic pathway has been developed for the preparation of imine-containing pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) and their dimers. Selective reduction of aromatic azides as well as aliphatic amides in a single step leading to an intramolecular reductive cyclization process by employing LiAlH4 or LiBH4 provides the cyclized imines.
Keywords
Azides , Intramolecular reductive cyclization , LiAlH4 , 4]benzodiazepines , LiBH4 , Amides
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858354
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