Title of article :
Synthesis of potent BCRP inhibitor—Ko143
Author/Authors :
Li، نويسنده , , Yuexian and Hayman، نويسنده , , Erik and Plesescu، نويسنده , , Mihaela and Prakash، نويسنده , , Shimoga R.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
Two routes for the synthesis of potent BCRP inhibitor—Ko143 are reported. The key intermediate, 6-methoxytryptophan derivative, was synthesized by an improved procedure, ytterbium triflate-promoted coupling between 6-methoxyindole and optically active 1-benzyl-2-methyl-(S)-1,2-aziridinecarboxylate in the second protocol.
Keywords :
BCRP inhibitor , ytterbium triflate , Aziridinecarboxylate , Ko143
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
