Author/Authors :
Takada، نويسنده , , Keisuke and Takemura، نويسنده , , Nobuko and Cho، نويسنده , , Kaori and Sohtome، نويسنده , , Yoshihiro and Nagasawa، نويسنده , , Kazuo، نويسنده ,
Abstract :
Asymmetric nitroaldol reaction of α-ketoesters was explored using a guanidine–thiourea bifunctional organocatalyst at temperatures below the freezing point of water. The new reaction protocol can be applied to the nitroaldol reaction of nitroalkanes and α-ketoesters to construct the adjacent stereocenters of the chiral tertiary alcohol product with high diastereo- and enantioselectivity.
