Title of article
Efficient preparation of 4-methoxy-5,6-dihydro-2H-pyran
Author/Authors
Panchal، نويسنده , , Nitesh and Fernandez-Yarza، نويسنده , , Arantxa and Free، نويسنده , , Paul and Gaffney، نويسنده , , Piers R.J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
1836
To page
1838
Abstract
We report the efficient synthesis of 4-methoxy-5,6-dihydro-2H-pyran (MDHP) via the TiCl4 driven elimination of MeOH from 4,4-dimethoxytetrahydropyran. The previous difficulty of preparing MDHP restricted the wider use of 4-methoxytetrahydropyran-4-yl (MTHP) acyclic acetals, which have desirable protecting group properties when compared to more commonly used MOM- and THP-acetals. The behaviour of the elimination on related acetals is also examined.
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858545
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