Title of article :
A first high enantiocontrol of an asymmetric tertiary carbon center attached with a fluoroalkyl group via Rh(I)-catalyzed conjugate addition reaction
Author/Authors :
Konno، نويسنده , , Tsutomu and Tanaka، نويسنده , , Tomoo and Miyabe، نويسنده , , Tomotsugu and Morigaki، نويسنده , , Atsunori and Ishihara، نويسنده , , Takashi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
Treatment of fluoroalkylated electron-deficient olefins with various boronic acids in the presence of a catalytic amount of Rh(I) coordinated with (S)-BINAP in toluene/H2O at the reflux temperature for 3 h gave the corresponding conjugate addition products with high enantioselectivity in high yields.
Keywords :
conjugate addition , Fluorine-containing compounds , Asymmetric tertiary carbon , enantioselective synthesis , Rhodium
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
