Title of article
A first high enantiocontrol of an asymmetric tertiary carbon center attached with a fluoroalkyl group via Rh(I)-catalyzed conjugate addition reaction
Author/Authors
Konno، نويسنده , , Tsutomu and Tanaka، نويسنده , , Tomoo and Miyabe، نويسنده , , Tomotsugu and Morigaki، نويسنده , , Atsunori and Ishihara، نويسنده , , Takashi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
5
From page
2106
To page
2110
Abstract
Treatment of fluoroalkylated electron-deficient olefins with various boronic acids in the presence of a catalytic amount of Rh(I) coordinated with (S)-BINAP in toluene/H2O at the reflux temperature for 3 h gave the corresponding conjugate addition products with high enantioselectivity in high yields.
Keywords
conjugate addition , Fluorine-containing compounds , Asymmetric tertiary carbon , enantioselective synthesis , Rhodium
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858694
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