Author/Authors :
Bailey، نويسنده , , Patrick D. and Beard، نويسنده , , Mark A. and Dang، نويسنده , , Hoa P.T. and Phillips، نويسنده , , Theresa R. and Price، نويسنده , , Richard A. and Whittaker، نويسنده , , James H.، نويسنده ,
Abstract :
N-Debenzylations using catalytic hydrogenolysis often fail to take place unless alcoholic solvents are used, but this can lead to N-alkylation as a side reaction; using trifluoroethanol as the solvent overcomes this problem, and leads to highly reliable hydrogenolyses for a wide range of substrates, including the final deprotection step in our total synthesis of (−)-raumacline.
