Author/Authors :
Min، نويسنده , , Byoung J. and Gu، نويسنده , , Xuyuan and Yamamoto، نويسنده , , Takashi and Petrov، نويسنده , , Ravil R. and Qu، نويسنده , , Hongchang and Lee، نويسنده , , Yeon Sun and Hruby، نويسنده , , Victor J.، نويسنده ,
Abstract :
A substituted hydropyrazino[1,2-a]pyrimidin-6-one derivative was synthesized stereoselectively via the intramolecular N-acyliminium ion cyclization between an amide nitrogen and an Nα-acetal derived from Cbz-protected aminopropyl-phenylalaninamide in very good yields. The formation of a single diastereomer is due to the low energy chairlike conformation of its bicyclic structure. This methodology provides a convenient tool to build internal bicyclic peptidomimetics.
