Title of article
Synthesis of a novel benzyl-octahydropyrazino[1,2-a]pyrimidin-6-one derivative as a convenient internal bicyclic peptidomimetic
Author/Authors
Min، نويسنده , , Byoung J. and Gu، نويسنده , , Xuyuan and Yamamoto، نويسنده , , Takashi and Petrov، نويسنده , , Ravil R. and Qu، نويسنده , , Hongchang and Lee، نويسنده , , Yeon Sun and Hruby، نويسنده , , Victor J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
2316
To page
2319
Abstract
A substituted hydropyrazino[1,2-a]pyrimidin-6-one derivative was synthesized stereoselectively via the intramolecular N-acyliminium ion cyclization between an amide nitrogen and an Nα-acetal derived from Cbz-protected aminopropyl-phenylalaninamide in very good yields. The formation of a single diastereomer is due to the low energy chairlike conformation of its bicyclic structure. This methodology provides a convenient tool to build internal bicyclic peptidomimetics.
Keywords
acetals , Internal bicyclic peptidomimetics , N-Acylimnium ion cyclization
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858804
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