Title of article
A route to functionalized pyrimidines from carbohydrates via amine-driven dehydrative ring transformations
Author/Authors
Yadav، نويسنده , , Lal Dhar S. and Awasthi، نويسنده , , Chhama and Rai، نويسنده , , Vijai K. and Rai، نويسنده , , Ankita، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
2377
To page
2380
Abstract
A novel and expeditious synthetic protocol for functionalized pyrimidines using unprotected aldoses as biorenewable resources is reported. The synthesis involves aza-Michael addition of aromatic amines to aldose-derived 1,3-oxazin-2-ones(thiones) followed by dehydrative ring transformation to afford 4-polyhydroxyalkylpyrimidin-2-ones(thiones) in excellent yields. This is a one-pot Montmorillonite K-10 clay-catalyzed amine-driven process proceeding under solvent-free microwave irradiation conditions.
Keywords
Mineral-catalyzed , 1 , pyrimidines , carbohydrates , 3-Oxazin-2-ones(thiones) , solvent-free , Microwaves
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858829
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