Title of article
First example of the coupling of α-diazoketones with thiourea: a novel route for the synthesis of 2-aminothiazoles
Author/Authors
Yadav، نويسنده , , J.S. and Reddy، نويسنده , , B.V. Subba and Rao، نويسنده , , Y. Gopala and Narsaiah، نويسنده , , A.V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
2381
To page
2383
Abstract
α-Diazoketones undergo smooth coupling with thiourea in the presence of 10 mol % of copper(II) triflate to produce the corresponding 2-aminothiazoles in excellent yields with high selectivity. The use of copper(II) triflate makes this method simple, convenient and practical. This method works well with both aryl and alkyl diazoketones to furnish a wide range of 2-aminothiazoles.
Keywords
diazoketones , Copper(II) salts , Carbene insertion reactions , 2-aminothiazoles
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858831
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