Title of article
First asymmetric total synthesis of (+)-curcutetraol
Author/Authors
Zhang، نويسنده , , Chenxia and Ito، نويسنده , , Suguru and Hosoda، نويسنده , , Naoya and Asami، نويسنده , , Masatoshi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
2552
To page
2554
Abstract
The first asymmetric total synthesis of (+)-curcutetraol, a marine phenolic bisabolane-type sesquiterpene, was achieved in eight steps in ca. 50% overall yield. The chiral tertiary benzylic alcohol moiety in the o-position of a phenol was constructed in high optical yield (99% ee) by an asymmetric synthesis using a chiral aminal, (2R,5S)-2-methoxycarbonyl-3-phenyl-1,3-diazabicyclo[3.3.0]octane.
Keywords
Curcutetraol , Asymmetric total synthesis , sesquiterpene , Tertiary benzylic alcohol
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858910
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