Title of article
Novel erythromycin A 9-tritylhydrazone: selective 6-O-methylation and conformational analysis
Author/Authors
Brunet، نويسنده , , Ernesto and Parra، نويسنده , , Francisco and Mantecَn، نويسنده , , Susana and Juanes، نويسنده , , Olga and Rodrيguez-Ubis، نويسنده , , Juan Carlos and Cruzado، نويسنده , , Ma Carmen and Asensio، نويسنده , , Ramَn، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
5
From page
2911
To page
2915
Abstract
The straightforward synthesis of the novel 9-tritylhydrazone erythromycin A and its highly regioselective O-methylation at C(6)–OH are described. Preliminary conformational data based on X-ray diffraction, 1H NMR and molecular mechanics is also presented with the aim of understanding the observed high regioselectivity. The facile synthesis of 6,12-O-dimethylerythromycin A, a standard to assess clarithromycin purity in quality control processes, is reported as well.
Keywords
Erythromycin , Clarithromycin , conformational analysis , Regioselective methylation
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1859081
Link To Document