Author/Authors :
Yang، نويسنده , , Xian-Wen and Li، نويسنده , , Su-Mei and Feng، نويسنده , , Lin and Shen، نويسنده , , Yun-Heng and Tian، نويسنده , , Jun-Mian and Zeng، نويسنده , , Hua-Wu and Liu، نويسنده , , Xiao-Hua and Shan، نويسنده , , Lei and Su، نويسنده , , Juan and Zhang، نويسنده , , Chuan and Zhang، نويسنده , , Wei-Dong، نويسنده ,
Abstract :
A novel biflavanol with unique six connective hexacyclic rings, abiesanol A (1), was isolated from the aerial parts of Abies georgei together with four known flavanols. The structure of new compound was elucidated mainly by the analysis of 1D and 2D NMR spectroscopic data. In addition, single-crystal X-ray diffraction analysis was adopted to confirm the structure of abiesanol A (1). In biological assay for inhibitory activities against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, abiesanol A (1) showed potent effects at 50 μg/mL with the inhibition rate of 43.0%. Under the same concentration, abiesanol A (1) did not show any cytotoxicity against RAW264.7 macrophages.
Keywords :
Abies georgei , Biflavanol , Pinaceae , Abiesanol A , Nitric oxide (NO) , RAW264.7 macrophages
