Author/Authors :
Levin، نويسنده , , Vitalij V. and Kozlov، نويسنده , , Mikhail A. and Song، نويسنده , , Young-Hun and Dilman، نويسنده , , Alexander D. and Belyakov، نويسنده , , Pavel A. and Struchkova، نويسنده , , Marina I. and Tartakovsky، نويسنده , , Vladimir A.، نويسنده ,
Abstract :
Iminium cations generated by the coupling of aldehydes, N-trimethylsilylamines and TMSOTf or by the methylation of imines with MeOTf smoothly react with silanes of a general formula Me3SiRf (Rf = CF3, CCl2F, C6F5) to afford the corresponding tertiary amines having a fluorinated substituent. The key step, involving C–C bond formation, is promoted by NaOAc or KF in DMF as a solvent.
Keywords :
Iminium ions , imines , Lewis bases , Fluorinated silanes
