Title of article
A concise synthesis of protected (2S,4R)-4-hydroxyornithine
Author/Authors
Pandey، نويسنده , , Satyendra Kumar and Pandey، نويسنده , , Menaka and Kumar، نويسنده , , Pradeep، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
3297
To page
3299
Abstract
A short synthesis of the nonproteinogenic amino acid, (2S,4R)-4-hydroxyornithine is described. Starting from racemic benzyl glycidol, the scaffold of the target compound was constructed in high enantio- and diastereoselectivity using Jacobsen’s hydrolytic kinetic resolution (HKR) and regioselective opening of an epoxide as key steps.
Keywords
epoxide , Grignard reaction , natural product , Hydroxyornithine , Jacobsen’s HKR
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1859249
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