Author/Authors :
Hwu، نويسنده , , Jih Ru and Yang، نويسنده , , Jhih-Ren and Tsay، نويسنده , , Shwu-Chen and Hsu، نويسنده , , Ming-Hua and Chen، نويسنده , , Yi-Chieh and Chou، نويسنده , , Shang-Shing P.، نويسنده ,
Abstract :
Various (heterocyclo)carbonyl mono-oxime esters of anthraquinone were synthesized, which exhibited an ability for DNA cleavage upon UV irradiation. Their structure–activity relationship was established, in which the most potent compound was anthraquinone O-9-(1,3-benzothiazole-2-carbonyl)oxime (4j). It can produce radical species and nick DNA at the concentration as low as 1.0 μM.
