Title of article
Photo-induced DNA cleavage by (heterocyclo)carbonyl oxime esters of anthraquinone
Author/Authors
Hwu، نويسنده , , Jih Ru and Yang، نويسنده , , Jhih-Ren and Tsay، نويسنده , , Shwu-Chen and Hsu، نويسنده , , Ming-Hua and Chen، نويسنده , , Yi-Chieh and Chou، نويسنده , , Shang-Shing P.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
3312
To page
3315
Abstract
Various (heterocyclo)carbonyl mono-oxime esters of anthraquinone were synthesized, which exhibited an ability for DNA cleavage upon UV irradiation. Their structure–activity relationship was established, in which the most potent compound was anthraquinone O-9-(1,3-benzothiazole-2-carbonyl)oxime (4j). It can produce radical species and nick DNA at the concentration as low as 1.0 μM.
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1859259
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