A one-pot efficient and fast Hiyama coupling using palladium nanoparticles in water under fluoride-free conditions

An efficient Hiyama cross-coupling of a wide variety of substituted aryl bromides and iodides with arylsilanes has been achieved at 100 °C in water through a simple one-pot operation using in situ generated palladium nanoparticles. This reaction is very fast (5 min) and has been performed in air under fluoride-free conditions, giving excellent chemoselectivity and high yields.