Title of article
Zn-mediated rhodium-catalyzed α-trifluoromethylation of ketones via silyl enol ethers
Author/Authors
Sato، نويسنده , , Kazuyuki and Yuki، نويسنده , , Takashi and Tarui، نويسنده , , Atsushi and Omote، نويسنده , , Masaaki and Kumadaki، نويسنده , , Itsumaro and Ando، نويسنده , , Akira، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
3558
To page
3561
Abstract
The treatment of silyl enol ethers of ketones with CF3–I and Et2Zn in the presence of RhCl(PPh3)3 in DME gave α-trifluoromethyl ketones in good yields. The reaction can be widely applicable to silyl enol ethers derived from aliphatic or aromatic ketones. In the absence of the rhodium catalyst, the reaction was very slow and the yields were quite poor.
Keywords
Rhodium , ?-Position , Silyl enol ether , fluorine , Trifluoromethyl
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1859362
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