Author/Authors :
Li، نويسنده , , Xing-Nuo and Lu، نويسنده , , Zhi-Qiang and Qin، نويسنده , , Song and Yan، نويسنده , , Haixia and Yang، نويسنده , , Min-Xin Guan، نويسنده , , Shuhong and Liu، نويسنده , , Xuan and Hua، نويسنده , , Huiming and Wu، نويسنده , , Lijun and Guo، نويسنده , , De-An، نويسنده ,
Abstract :
Tonkinensines A (1) and B (2), two novel cytisine-type alkaloids that feature the skeleton with a linkage to pterocarpan, were isolated from the roots of Sophora tonkinensis. Their structures and absolute configurations were elucidated by spectroscopic methods, especially X-ray crystal diffraction and CD spectral analysis. The proposed biosynthetic pathway was also discussed. Both 1 and 2 were tested in HeLa and MDA-MB-231 tumor cell lines, and compound 2 showed moderate cytotoxic activity.
Keywords :
Tonkinensine A , Tonkinensine B , Quinolizidine alkaloids , Sophora tonkinensis
