Author/Authors :
Sharma، نويسنده , , Anubha and Gamre، نويسنده , , Sunita and Roy، نويسنده , , Siddharth and Goswami، نويسنده , , Dibakar and Chattopadhyay، نويسنده , , Angshuman and Chattopadhyay، نويسنده , , Subrata، نويسنده ,
Abstract :
A facile asymmetric synthesis of the octalactin lactone was developed staring from (R)-cyclohexylideneglyceraldehyde (1). The key step of the synthesis is an In-mediated diastereoselective crotylation of 1 in water, which furnished the building blocks with the required stereochemistry under operationally simple conditions. Their conversion to the appropriate intermediates, invertive esterification and a ring closing metathesis reaction furnished the target compound.
Keywords :
Octalactin , asymmetric synthesis , Crotylation , Chiral pool
