Title of article :
Chemo- and regioselective ethynylation of 4,5,6,7-tetrahydroindoles with ethyl 3-halo-2-propynoates
Author/Authors :
Trofimov، نويسنده , , Boris A. and Sobenina، نويسنده , , Lyubov’ N. and Stepanova، نويسنده , , Zinaida V. and Petrova، نويسنده , , Ol’ga V. and Ushakov، نويسنده , , Igor’ A. and Mikhaleva، نويسنده , , Al’bina I.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
4,5,6,7-Tetrahydroindoles undergo a rapid, facile (rt, 60 min) ethynylation with ethyl 3-halo-2-propynoates upon grinding with solid K2CO3 (without solvent) at C-2 of the tetrahydroindole ring to afford ethyl 3-(4,5,6,7-tetrahydroindol-2-yl)-2-propynoates in 62–90% yield.
Keywords :
4 , Active surface , K2CO3 , cross-coupling , indoles , 6 , 5 , 7-Tetrahydroindoles
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
