Author/Authors :
Liao، نويسنده , , Xibin and Butora، نويسنده , , Gabor and Olsen، نويسنده , , David B. and Carroll، نويسنده , , Steven S. and McMasters، نويسنده , , Daniel R. and Leone، نويسنده , , Joseph F. and Stahlhut، نويسنده , , Mark and Doss، نويسنده , , George A. and Yang، نويسنده , , Lihu and MacCoss، نويسنده , , Malcolm، نويسنده ,
Abstract :
The synthesis of 2′-β-C-methyl-neplanocin derivatives is described. The key intermediate cyclopentenyl alcohol 12 is prepared from sugar 5 in 12 steps. Coupling of 12 with appropriately protected purine, 7-deaza pyrimidine, uracil and pyrimidine bases via the Mitsunobu reaction followed by deprotection afforded the target cyclopentenyl nucleosides (18–23, 27). The synthesized compounds were evaluated as potential inhibitors of the hepatitis C virus (HCV) in vitro. Unfortunately, none of them show anti-HCV activity below EC50 100 μM.
