Title of article :
Absolute stereostructures of cytotoxic metabolites, chaetomugilins A–C, produced by a Chaetomium species separated from a marine fish
Author/Authors :
Yamada، نويسنده , , Takeshi and Doi، نويسنده , , Mitunobu and Shigeta، نويسنده , , Hirohumi and Muroga، نويسنده , , Yasuhide and Hosoe، نويسنده , , Saki and Numata، نويسنده , , Atsushi and Tanaka، نويسنده , , Reiko، نويسنده ,
Abstract :
Chaetomugilins A–C were isolated from a strain of Chaetomium globosum originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques, some chemical transformations, and an X-ray analysis. This compound exhibited significant cytotoxicity against cultured P388 cells and HL-60 cells.
