A novel, microwave-assisted method for the synthesis of alicyclic-condensed 5H-1,4,6,7-tetrahydro-1,4-diazepin-5-ones

An efficient, high-yielding method has been developed for the synthesis of cycloalkane-fused and phenyl-substituted 1,4-diazepin-5-ones from β-amino acids. The process involves the oxidative cleavage of a terminal olefin bond and an acid-catalyzed, microwave-assisted intramolecular condensation step.