Title of article :
A new synthesis of potent antitumor saponin OSW-1 via Wittig rearrangement
Author/Authors :
Tsubuki، نويسنده , , Masayoshi and Matsuo، نويسنده , , Sohichiro and Honda، نويسنده , , Toshio، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
OSW-1 and its analogues in which thiophene ring was introduced at the side chain were synthesized employing Wittig rearrangement of 17E(20)-ethylidene-16α-(4′-methyl-2′-thienyl)methyloxy steroid. The synthesis required nine steps from the known 17E(20)-ethylidene-16α-hydroxy steroid in 15.6% overall yield.
Keywords :
OSW-1 , Analogues , Thiophene , Wittig rearrangement
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
