Author/Authors :
McNulty، نويسنده , , James and Das، نويسنده , , Priyabrata and Gosciniak، نويسنده , , Don، نويسنده ,
Abstract :
An efficient, stereoselective method for the synthesis of α-phosphonoenamines based on a modified Peterson olefination is described. The carbanion derived from isolatable intermediate 2 reacts with aromatic or aliphatic aldehydes selectively eliminating in Peterson fashion to deliver functionally rich α-phosphonoenamines 3. The synthetic utility of these enamines is demonstrated by their hydrolysis yielding the homologous carboxylic acids in good yield.
