Palladium-catalyzed Heck reaction under thermomorphic mode

Complex PdCl2(4,4′-bis-(n-C10F21CH2OCH2)-2,2′-bpy) (2b) was known to be a good recoverable catalyst under fluorous biphasic system. Complex 2b and PdCl2(4,4′-bis-(n-C11F23CH2OCH2)-2,2′-bpy) (2c), soluble in polar organic solvents at >120 °C but insoluble at 25 °C, were demonstrated here as catalysts in the Pd-catalyzed Heck reaction under the thermomorphic mode and recovered for reusage, that is, the Heck reaction is homogeneously carried out at ca 140 °C, and after reaction the product mixtures remain in solution with the catalyst heterogeneously separated at room temperature.