Title of article :
A practical, green, and selective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems using alumina-catalyzed Michael addition reaction
Author/Authors :
Castellano، نويسنده , , Sabrina and Bertamino، نويسنده , , Alessia and Gomez-Monterrey، نويسنده , , Isabel and Santoriello، نويسنده , , Marisabella and Grieco، نويسنده , , Paolo and Campiglia، نويسنده , , Pietro and Sbardella، نويسنده , , Gianluca and Novellino، نويسنده , , Ettore، نويسنده ,
Abstract :
A convenient method for double Michael additions to quinone systems catalyzed by Al2O3, is reported. The advantages of this method include the use of a cheap and environment-friendly catalyst, a straightforward isolation of the pure product by filtration, high yields, and excellent selectivity, thus providing rapid access to useful building blocks for the preparation of biologically active quinones.
