Author/Authors :
Katoh، نويسنده , , Takahiro and Watanabe، نويسنده , , Tsunefumi and Nishitani، نويسنده , , Mitsuyoshi and Ozeki، نويسنده , , Minoru and Kajimoto، نويسنده , , Tetsuya and Node، نويسنده , , Manabu، نويسنده ,
Abstract :
Demethylation of N-methyl group in N-methyl-N-arylmethyl-α-amino esters was accomplished by the oxidation of the amino group using the N-iodosuccinimide (NIS)/acetonitrile system followed by treatment with O-methylhydroxylamine hydrochloride. This combination of reagents could provide a complementary method to catalytic hydrogenolysis, which certainly cleaves N-arylmethyl groups, in organic synthesis.
