Author/Authors :
Campiglia، نويسنده , , Pietro and Aquino، نويسنده , , Claudio and Bertamino، نويسنده , , Alessia and Sala، نويسنده , , Marina and Gomez-Monterrey، نويسنده , , Isabel M. and Novellino، نويسنده , , Ettore and Grieco، نويسنده , , Paolo، نويسنده ,
Abstract :
An alternative method for the synthesis of pseudopeptides containing a ψ[CH2NH] amide bond surrogate is reported. The synthetic approach is based on a nucleophilic displacement of the chiral N-protected β-iodoamines with conveniently protected amino acid esters. The compatibility of this method with both conventional and microwave-assisted peptide synthesis should increase the potentiality of the ψ[CH2NH] peptide bond isostere in peptide chemistry.
