Title of article :
RCM-mediated stereoselective synthesis of three novel tetrahydroisoquinoline tetracyclic core frameworks
Author/Authors :
Huang، نويسنده , , Qingqing and Chen، نويسنده , , Lin-Hai and Nan، نويسنده , , Fa-Jun، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
Three novel tetrahydroisoquinoline tetracyclic core frameworks were stereoselectively synthesized. The key steps included a ring-closing metathesis (RCM)-mediated cyclization and a subsequent intramolecular SN2 N(O)-substituted reaction. This simple method for tetracyclic core synthesis facilitates the further exploration of the chemical space of tetrahydroisoquinoline alkaloids.
Keywords :
Tetrahydroisoquinoline , ring-closing metathesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters