Title of article :
Synthesis of sterically-hindered peptidomimetics using 4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methyl-morpholinium chloride
Author/Authors :
Shieh، نويسنده , , Wen-Chung and Chen، نويسنده , , Zhuoliang and Xue، نويسنده , , Song and McKenna، نويسنده , , Joe and Wang، نويسنده , , Run-Ming and Prasad، نويسنده , , Kapa and Repic، نويسنده , , Oljan and Blacklock، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
Our study demonstrated that 4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methyl-morpholinium chloride (DMTMM) is a versatile coupling reagent for the synthesis of sterically-hindered peptidomimetics. It is superior to HBTU/HOBt and CDMT in controlling racemization and N-arylation, respectively.
Keywords :
6-dimethoxy-1 , 3 , 5-triazine-2-yl)-4-methyl-morpholinium chloride , DMTMM , Racemization control , Sterically-hindered peptide synthesis , 4-(4
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
