Title of article
Preparation of MBHA resin by benzotriazole-mediated amidoalkylation
Author/Authors
Lee، نويسنده , , Tae-Kyung and Choi، نويسنده , , Jeong-Hyun and Byun، نويسنده , , Jang-Woong and Lee، نويسنده , , Yoon-Sik، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
5380
To page
5382
Abstract
MBHA (4-methylbenzhydrylamine) resin is widely used as a solid support for the synthesis of carboxamides or peptide C-terminal amides. Herein, we report a new method for synthesizing MBHA resin by benzotriazole-mediated amidoalkylation. MBHA resin was efficiently prepared with N-[(benzotriazol-1-yl)(p-tolyl)methyl]formamide or N-[formamido(p-tolyl)methyl]formamide, and it showed excellent properties as a solid support.
Keywords
Solid-phase peptide synthesis , MBHA resin , 1-Benzotriazole , Amidoalkylation
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1860795
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