Title of article :
Enantioselective direct vinylogous Michael addition reaction catalyzed by organic molecules
Author/Authors :
Lu، نويسنده , , Jun and Liu، نويسنده , , Feng and Zhou، نويسنده , , Wei-Juan and Loh، نويسنده , , Teck-Peng، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
Chiral 2-azanorbornyl-3-methanol is used as an organocatalyst for the highly enantioselective direct vinylogous Michael addition reaction of vinyl malononitriles to α,β-unsaturated aldehydes. In many cases, the products can be obtained in almost optically pure form (>95% ee) after a single recrystallization.
Keywords :
organocatalysis , Unsaturated aldehyde , Michael addition , Dicyanoolefin , Chiral azabicyclo catalyst
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
