Title of article
The first application of the Baylis–Hillman reaction in azetidine chemistry: a convenient synthesis of azetidine-3-carbonitriles/carboxylates
Author/Authors
Yadav، نويسنده , , Lal Dhar S. and Srivastava، نويسنده , , Vishnu P. and Patel، نويسنده , , Rajesh، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
5652
To page
5654
Abstract
The first application of Baylis–Hillman adducts in the synthesis of azetidines is reported. The synthesis involves a one-pot, high yielding and highly diastereoselective annulation of unmodified Baylis–Hillman adducts with N-arylphosphoramidates to afford 1,2-disubstituted azetidine-3-carbonitriles/carboxylates, which are the precursors of biologically versatile azetidine-3-carboxylic acids.
Keywords
Phosphoramidates , Michael-addition , Cyclization reactions , stereoselective synthesis , azetidines , Baylis–Hillman adducts
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1860921
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