Title of article :
Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton’s Jelly and bone marrow sources
Author/Authors :
Najar، نويسنده , , Mehdi and Raicevic، نويسنده , , Gordana and Boufker، نويسنده , , Hicham Id and Kazan، نويسنده , , Hussein Fayyad and Bruyn، نويسنده , , Cécile De and Meuleman، نويسنده , , Nathalie and Bron، نويسنده , , Dominique and Toungouz، نويسنده , , Michel and Lagneaux، نويسنده , , Laurence، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Abstract :
Due to their immunomodulatory properties, adipose tissue (AT) and Wharton’s Jelly (WJ) constitute valuable alternatives to BM as sources of MSCs for managing graft-versus-host disease. To ensure the efficiency of AT- and WJ-MSCs implies the characterization of their immunomodulatory functions in comparison to those of BM. In this study, we investigated the capacity of AT- and WJ-MSCs to modulate lymphocyte reactions in response to different stimuli as well as the specificity of this immunomodulation. AT- and WJ-MSC displayed potent immunosuppressive effects on lymphocyte responses in a dose-dependent manner. These effects included the prevention of lymphocyte activation as well as the suppression of T-cell proliferation regardless of the stimuli used to activate lymphocytes. These effects were mediated through the expression of COX1/COX2 enzymes and by the production of PGE2. CD4+ and CD8+ T-lymphocytes were equally targeted by MSCs demonstrating that the immunomodulation was not restricted to a specific T-cell subpopulation.
Keywords :
Mesenchymal stromal cells , Bone marrow , Wharton’s jelly , Immunomodulation , Prostaglandin E2 (PGE2) , Lymphocyte activation/proliferation , adipose tissue , T-cell subsets , Hepatic growth factor (HGF)
Journal title :
Cellular Immunology
Journal title :
Cellular Immunology