Title of article
Efficient synthesis of racemic β-aminophosphonates via aza-Michael reaction in water
Author/Authors
Matveeva، نويسنده , , Ekaterina V. and Petrovskii، نويسنده , , Pavel V. and Odinets، نويسنده , , Irina L.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
5
From page
6129
To page
6133
Abstract
Water as a solvent significantly accelerates the addition of various amines to diethyl vinylphosphonate to yield β-aminophosphonates without any catalyst compared to known procedures for such aza-Michael reactions. The products are obtained in quantitative yields and high purity over short reaction times. Using a reactant ratio (vinylphosphonate/amine) of 2:1 resulted in double phosphorylation of primary amines.
Keywords
Aza-Michael reaction , ?-Aminophosphonic acid , Amines , water , Vinylphosphonate , ?-Aminophosphonates
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1861244
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