Author/Authors :
Saunders، نويسنده , , Kevin O. and Ward-Caviness، نويسنده , , Cavin and Schutte، نويسنده , , Robert J. and Freel، نويسنده , , Stephanie A. and Overman، نويسنده , , R. Glenn and Thielman، نويسنده , , Nathan M. and Cunningham، نويسنده , , Coleen K. and Kepler، نويسنده , , Thomas B. and Tomaras، نويسنده , , Georgia D.، نويسنده ,
Abstract :
CD8+ T-lymphocytes can utilize noncytolytic mechanisms to suppress HIV-1 replication through the secretion of soluble factors. The secretion of MIP-1β, MIP-1α, IP-10, MIG, IL-1α, and interferon gamma correlated most strongly with soluble noncytolytic suppression (p < 0.0001). Since the noncytolytic response is impaired by histone hyperacetylation, we examined the ability of histone hyperacetylation to alter the expression of immune-related genes. MIP-1α and IP-10 were also among the genes that were down-regulated by histone hyperacetylation. We define a multifactorial cytokine profile of CD8+ T-lymphocytes capable of mediating noncytolytic suppression of CXCR4-tropic HIV-1 replication.
Keywords :
CD8+ T-lymphocyte , cytokines , Noncytolytic suppression , HIV-1 , Chemokine
