Author/Authors :
Na، نويسنده , , MinKyun and Meujo، نويسنده , , Damaris A.F. and Kevin، نويسنده , , Dion and Hamann، نويسنده , , Mark T. and Anderson، نويسنده , , Matthew R. Hill، نويسنده , , Russell T.، نويسنده ,
Abstract :
The antimalarial guided fractionation of the culture of marine Streptomyces sp. strain H668 led to the isolation of a new polyether metabolite. The structure was determined by comprehensive NMR and MS assignments. This new metabolite showed in vitro antimalarial activity against both the chloroquine-susceptible (D6) and-resistant (W2) clones of Plasmodium falciparum, without cytotoxicity to normal cells (Vero) making it a promising first lead from this marine bacterium.
