Title of article
An expeditious synthesis of 3-(difluoromethoxy)- and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines
Author/Authors
Guiadeen، نويسنده , , Deodialsingh and Kothandaraman، نويسنده , , Shankaran and Yang، نويسنده , , Lihu and Mills، نويسنده , , Sander G. and MacCoss، نويسنده , , Malcolm، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
6368
To page
6370
Abstract
An expeditious and concise synthesis of 3-(difluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridine and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines is described. Starting from N-benzyl piperidone, the key intermediates leading to these two biologically desirable synthones were rapidly assembled by inverse electron demand Diels–Alder (IEDA) reaction utilizing microwave irradiation. The scope of the microwave methodology developed herein was extended to other ketones.
Keywords
Difluoromethoxy , microwave , Trifluoromethoxy
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1861403
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