Title of article :
Design, synthesis, and biological evaluation of a dansyled amino acid derivative as an imaging agent for apoptosis
Author/Authors :
Zeng، نويسنده , , Wenbin and Miao، نويسنده , , Weimin and Kabalka، نويسنده , , George and Puil، نويسنده , , Michael Le and Biggerstaff، نويسنده , , John and Townsend، نويسنده , , David، نويسنده ,
Abstract :
To develop a small molecule-based biomarker for in vivo apoptosis imaging, a dansyled amino acid derivative (BNSBA) was designed and synthesized in good yield. The biological evaluation demonstrated that BNSBA selectively binds to apoptotic cancer cells and is localized within the cytoplasm of cells that bound annexin V on the plasma membrane.
Keywords :
Amino acid , Imaging , Biomarker , apoptosis
