Title of article
Dual-reagent organocatalysis with a phosphine and electron-deficient alkene: application to the Henry reaction
Author/Authors
Wang، نويسنده , , Xiu-hui FANG، نويسنده , , Fan and Zhao، نويسنده , , Chen and Tian، نويسنده , , Shi-Kai، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
6442
To page
6444
Abstract
Triphenylphosphine in combination with methyl acrylate was found to be able to catalyze the Henry (nitroaldol) reaction of various aldehydes and α-keto esters to give the corresponding β-nitroalkanols in good to excellent yields, and a catalytic cycle involving a zwitterionic phosphine–alkene adduct was proposed for this dual-reagent organocatalysis according to the deuterium-labeling experiments with CD3NO2.
Keywords
phosphines , The Henry reaction , Electron-deficient alkenes , Aldehydes , Nitroalkanes
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1861450
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