Title of article
A convenient transformation of α-alkylserines into α-halogenomethyl-α-alkylglycines
Author/Authors
Aleksandra and Kudaj، نويسنده , , Adam and Olma، نويسنده , , Aleksandra، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
6445
To page
6447
Abstract
An efficient and facile synthesis of N-Boc-α-chloromethyl- and α-bromomethyl-α-alkylglycines is reported that involves cyclization of N-Boc-α-alkylserines to the corresponding β-lactones under Mitsunobu reaction conditions, followed by ring opening with anhydrous MgCl2 or MgBr2.
Keywords
N-Boc-?-alkylserine ?-lactones , N-Boc-?-chloromethyl-?-alkylglycines , ? , ?-disubstituted glycines , Mitsunobu reaction , N-Boc-?-bromomethyl-?-alkylglycines
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1861452
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