Title of article :
Total synthesis of (−)-centrolobine
Author/Authors :
Takeuchi، نويسنده , , Toshiharu and Matsuhashi، نويسنده , , Miyuki and Nakata، نويسنده , , Tadashi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
Stereoselective synthesis of (−)-centrolobine, an anti-Leishmania agent, was accomplished via an intramolecular Barbier-type reaction of iodo-ester with n- or t-butyllithium followed by Lewis acid-promoted Et3SiH reduction of the resulting hemiacetal.
Keywords :
Butyllithium , 2 , cyclization , CBS reduction , 6-syn-Tetrahydropyran , Mitsunobu reaction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
