Title of article
New synthetic method for 2,3-trans-2-methyl-tetrahydropyran-3-ol and oxepan-3-ol by unique insertion of a methyl group
Author/Authors
Kimishima، نويسنده , , Atsushi and Nakata، نويسنده , , Tadashi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
6563
To page
6565
Abstract
Treatment of tetrahydropyran-3-ol and oxepan-3-ol derivatives, which have a 1′-mesyloxy group at the C-2 side chain, with Me3Al effected removal of the mesyloxy group, 1,2-hydride shift, and stereoselective insertion of a methyl group into the resulting oxonium ion, giving 2,3-trans-2-methyl-tetrahydropyran-3-ol and oxepan-3-ol derivatives, respectively.
Keywords
Mesylate , Trimethylaluminum , 2-Methyl-oxepane , 2-Methyl-tetrahydropyran , polycyclic ether
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1861530
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