Author/Authors :
Onomura، نويسنده , , Osamu and Moriyama، نويسنده , , Atsushi and Fukae، نويسنده , , Kazuhiro and Yamamoto، نويسنده , , Yutaka and Maki، نويسنده , , Toshihide and Matsumura، نويسنده , , Yoshihiro and Demizu، نويسنده , , Yosuke، نويسنده ,
Abstract :
Oxidative carbon–carbon bond cleavage of N-alkoxycarbonylated cyclic amines was accomplished by NaNO2 in TFA to afford ω-amino carboxylic acid in high yield. Optically active 3-hydroxypiperidine derivatives and 3-pipecolinate were converted to enantiomerically pure (R)-4-amino-3-hydroxybutanoic acid (GABOB) and (S)-2-pyrrolidone-4-carboxylate, respectively.
Keywords :
?-Amino acid , Cyclic amines , Carbon–carbon cleavage , Sodium Nitrite , trifluoroacetic acid
