Author/Authors :
Zhang، نويسنده , , Mingxia and Wang، نويسنده , , Zheng and Graner، نويسنده , , Michael W. and Yang، نويسنده , , Lin and Liao، نويسنده , , Mingfeng and Yang، نويسنده , , Qianting and Gou، نويسنده , , Jizhou and Zhu، نويسنده , , Yuzhen and Wu، نويسنده , , Chi and Liu، نويسنده , , Haiying and Zhou، نويسنده , , Boping and Chen، نويسنده , , Xinchun، نويسنده ,
Abstract :
Although it has been recognized that ectopic follicle-like B cell aggregate formation is common in the lungs of patients with tuberculosis, the role of infiltrated B cells in human tuberculosis remains to be elucidated. In the present study, we showed that ectopic B cell aggregate formation was associated with containment of Mycobacterium tuberculosis. The area ratio of ectopic B cell aggregates was correlated with localized IL-17 mRNA expression and peripheral TGF-β and IL-6 mRNA expression. Depletion of B cells from pleural fluid mononuclear cells resulted in significantly diminished M. tuberculosis antigen-specific IL-17 and IL-22 production, but not in IFN-γ secretion. Therefore, ectopic lung B cell formation is important for containment of M. tuberculosis, and up-regulation of IL-17 and IL-22 responses may be an important mechanism underlying the protective role B cells in human tuberculosis.
Keywords :
Mycobacterium tuberculosis , B cells , IL-22 , IL-17
