Title of article
A short enantioselective synthesis of (−)-bestatin via l-proline-catalyzed α-amination of an aldehyde
Author/Authors
George، نويسنده , , Shyla and Suryavanshi، نويسنده , , Gurunath S. and Sudalai، نويسنده , , Arumugam، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
6791
To page
6793
Abstract
A short and high yielding enantioselective synthesis of (−)-bestatin, a naturally occurring aminopeptidase inhibitor, is described via l-proline-catalyzed asymmetric α-amination of 3-phenylpropionaldehyde as the key reaction. The methodology also involves a Pd-catalyzed intramolecular cyclization of an allylic acetate giving a trans-oxazoline in a highly diastereoselective manner (dr > 14:1).
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1861670
Link To Document